Note this is for JAWS 7.0 since I don't know if the script was included in earlier versions or not. I don't think so, no matter here are the steps.

1 In either outlook express or Outlook hit insert+F2 to bring up your list of managers.
2 Hit the letter K for keyboard manager.
3 Hit enter.
4 Tab once.
5 Hit the letter S and arrow up until you hear reply directly to sender.
It's just faster that way because there are a lot of scripts that start with an R, and it's the last in the line.
6 Hit control+A
7 Pick what ever keystroke you want to use. I used alt+R myself.
8 tab over to the OK button or just hit enter.

You will receive a prompt asking if you want to modify your keyboard manager file, hit enter. Then alt+F4 out of your keyboard manager because you're done.

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